Antihypertensive Effect of Sesamin. I. Protection against Deoxycorticosterone Acetate-Salt-Induced Hypertension and Cardiovascular Hypertrophy.
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چکیده
منابع مشابه
Antihypertensive effects of chicken extract against deoxycorticosterone acetate-salt-induced hypertension in rats.
We investigated the antihypertensive effect of Brand's Essence of Chicken (BEC), a popular chicken extract used as a traditional remedy, using deoxycorticosterone acetate (DOCA)-salt hypertensive rats. Animals were unilaterally nephrectomized, and then separated into a sham-operated group (sham group) and a DOCA-salt-treated group. The latter was further separated into a normal diet group and a...
متن کاملImpaired cardiovascular reflexes precede deoxycorticosterone acetate-salt hypertension.
We hypothesized that impaired cardiopulmonary reflexes but not altered baroreceptor reflexes precede deoxycorticosterone acetate (DOCA)-salt hypertension. Uninephrectomized rats were given either DOCA and 0.9% NaCl as drinking water, 0.9% NaCl alone, or tap water. We measured mean blood pressure, heart rate, and renal sympathetic nerve activity. After 8 days, mean blood pressure was not differe...
متن کاملAxl mediates vascular remodeling induced by deoxycorticosterone acetate-salt hypertension.
Axl, a receptor tyrosine kinase, was recently identified as a novel candidate gene in a genetic model of salt-sensitive hypertension (Sabra rat). Our group first reported that Axl plays a significant role in vascular remodeling in response to injury. Here we investigated the role of Axl in the pathogenesis of hypertension in a deoxycorticosterone acetate (DOCA)-salt model. Hypertension was indu...
متن کاملChronic hyperinsulinemia augments deoxycorticosterone acetate-salt hypertension.
To evaluate the effect of chronic hyperinsulinemia on blood pressure in salt-dependent hypertension, we infused insulin (1.0 IU/d, n = 15) or saline (n = 13) for 4 weeks into deoxycorticosterone acetate-salt hypertensive rats. The insulin infusion increased plasma insulin levels to 24 +/- 2 microU/mL, which was higher than in the saline-infused rats (9 +/- 1 microU/mL) but was still within the ...
متن کاملPolyamines, vascular smooth muscle, and deoxycorticosterone acetate-salt hypertension.
This study was performed to determine if an alteration in vascular polyamine contents is associated with the development of deoxycorticosterone acetate-salt hypertension. The effects of chronic administration of alpha-difluoromethylornithine, a specific irreversible inhibitor of ornithine decarboxylase and thus polyamine biosynthesis, on vascular polyamine contents, structure, and function as w...
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ژورنال
عنوان ژورنال: Biological and Pharmaceutical Bulletin
سال: 1995
ISSN: 0918-6158,1347-5215
DOI: 10.1248/bpb.18.1016